Del2313_PNC1

(YGL037C)

Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress (From theSaccharomyces Genome Database)

MAT	SD3174b: a/alpha	SD3174b2: a/alpha	SD3175b: a/alpha	SD3175b2: a/alpha
Aneuploidies/GCR	SD3174b	SD3174b2	SD3175b	SD3175b2	Chromosome ploidy SD3174b SD3174b2 SD3175b SD3175b2 chr1 2.00 2.00 2.00 2.00 chr2 2.00 2.00 2.00 2.00 chr3 2.00 2.00 2.00 2.00 chr4 2.00 2.00 2.00 2.00 chr5 2.00 2.00 2.00 2.00 chr6 2.00 2.00 2.00 2.00 chr7 2.00 2.00 2.00 2.00 chr8 2.00 2.00 2.00 2.00 chr9 2.00 2.00 2.00 2.00 chr10 2.00 2.00 2.00 2.00 chr11 2.00 2.00 2.00 2.00 chr12 2.00 2.00 2.00 2.00 chr13 2.00 2.00 2.00 2.00 chr14 2.00 2.00 2.00 2.00 chr15 2.00 2.00 2.00 2.00 chr16 2.00 2.00 2.00 2.00
Locus Snapshot	SD3174b	SD3174b2	SD3175b	SD3175b2
	SD3174b	SD3174b2	SD3175b	SD3175b2
Secondary mutations	Homozygous - - - Heterozygous IX 391184 YIR019C FLO11 S831T X 422857 YJL007C T52:G>A:3 XIII 88219 YML091C RPM2 T838N	Homozygous - - - Heterozygous IX 391459 YIR019C FLO11 T739:A>G:3 VIII 527200 YHR211W FLO5 T603:T>C:3 X 422857 YJL007C T52:G>A:3	Homozygous - - - Heterozygous IV 836787 YDR188W CCT6 E123K IV 897206 YDR216W ADR1 K724:G>A:3 IV 1273055 YDR402C DIT2 F217L VIII 527200 YHR211W FLO5 T603:T>C:3 X 422857 YJL007C T52:G>A:3 XV 138964 YOL096C COQ3 Δ27	Homozygous - - - Heterozygous II 545364 YBR151W APD1 N113H X 422857 YJL007C T52:G>A:3